Mouse Protein Tyrosine Phosphatase Receptor Type N,PTPRN ELI

Plays a role in vesicle-mediated secretory processes (PubMed:21732083).

Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets.

Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:15939893, PubMed:21732083).

Plays a role in insulin secretion in response to glucose stimuli (PubMed:12031972, PubMed:21732083).

Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (PubMed:16269463).

In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (PubMed:16269463).

Seems to lack intrinsic enzyme activity (PubMed:7980563, PubMed:8878556).

Required to maintain normal levels of renin expression and renin release (PubMed:19019914).

May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (PubMed:12364328).

{ECO:0000250|UniProtKB:Q16849, ECO:0000269|PubMed:12031972, ECO:0000269|PubMed:12364328, ECO:0000269|PubMed:15939893, ECO:0000269|PubMed:19019914, ECO:0000269|PubMed:7980563, ECO:0000269|PubMed:8878556}.; [ICA512-transmembrane fragment]: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2 (By similarity).

{ECO:0000250|UniProtKB:Q16849}.; [ICA512-cleaved cytosolic fragment]: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (By similarity).

Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:18178618).

ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (By similarity).

{ECO:0000250|UniProtKB:Q16849, ECO:0000269|PubMed:18178618}.