Mouse Protein Wnt-5A, WNT5AELI

Ligand for members of the frizzled family of seven transmembrane receptors (PubMed: 17117926).

Can activate or inhibit canonical Wnt signaling, depending on receptor context (PubMed: 16602827).

In the presence of FZD4, activates beta-catenin signaling.

In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (PubMed: 16602827).

Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation.

Stimulates cell migration (PubMed: 17117926).

Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor.

Mediates motility of melanoma cells (By similarity).

Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle (PubMed: 10021340).

Inhibits type II collagen expression in chondrocytes (By similarity).