Mouse Protein Wnt-7a,WNT7A ELI
3,140.00 ₪
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:18230341, PubMed:20530549, PubMed:23629626).
Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:7885472, PubMed:9769174, PubMed:9790192).
Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:28803732).
Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (PubMed:9790192).
Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (PubMed:23629626).
Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (PubMed:23629626).
Promotes formation of synapses via its interaction with FZD5 (PubMed:20530549).
{ECO:0000269|PubMed:18230341, ECO:0000269|PubMed:20530549, ECO:0000269|PubMed:23629626, ECO:0000269|PubMed:28803732, ECO:0000269|PubMed:7885472, ECO:0000269|PubMed:9769174, ECO:0000269|PubMed:9790192}.
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