Mouse Rho Guanine Nucleotide Exchange Factor 1,ARHGEF1 ELI

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits.

Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase.

Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain.

This GEF activity is inhibited by binding to activated GNA12.

Mediates angiotensin-2-induced RhoA activation.

Isoform 3 and isoform 4 do not homooligomerize and show an enhanced RhoGEF activity.

{ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:8910315}.