Mouse Secreted Frizzled Related Protein 4,SFRP4 ELI

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts.

They have a role in regulating cell growth and differentiation in specific cell types (PubMed:27355534).

SFRP4 plays a role in bone morphogenesis (PubMed:27355534).

May also act as a regulator of adult uterine morphology and function.

May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity).

Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity).

{ECO:0000250|UniProtKB:Q6FHJ7, ECO:0000250|UniProtKB:Q9JLS4, ECO:0000269|PubMed:27355534}.