Mouse Serine;threonine-protein kinase VRK1,VRK1 ELI

Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation.

Acts by mediating phosphorylation of downstream target protein.

Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2.

Phosphorylates casein and histone H3.

Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm.

Phosphorylates ATF2 which activates its transcriptional activity (By similarity).

{ECO:0000250, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:9521809}.