Mouse Sialidase-4,NEU4 ELI
3,140.00 ₪
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides.
Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:19506080, PubMed:22393058).
Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (PubMed:19506080, PubMed:22393058).
May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (By similarity).
Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:19506080, PubMed:22393058).
{ECO:0000250|UniProtKB:Q8WWR8, ECO:0000269|PubMed:19506080, ECO:0000269|PubMed:22393058}.
Quantity