Mouse Soluble Endoglin,sENG ELI
3,140.00 ₪
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:10625534).
Required for normal structure and integrity of adult vasculature (By similarity).
Regulates the migration of vascular endothelial cells (PubMed:17540773).
Required for normal extraembryonic angiogenesis and for embryonic heart development (PubMed:10625534).
May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (PubMed:28530658).
May play a role in the binding of endothelial cells to integrins.
Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:23300529).
Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity).
{ECO:0000250|UniProtKB:P17813, ECO:0000269|PubMed:10625534, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:28530658}.
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