Mouse Sorbitol Dehydrogenase, SDH ELI

Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols (By similarity).

Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose (PubMed: 6852349).

Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity).

May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility and protein tyrosine phosphorylation (PubMed: 18799757).

Has no activity on ethanol.

Cannot use NADP(+) as the electron acceptor (PubMed: 6852349).