Mouse STEAP family member 4,Steap4 ELI

Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:16609065).

Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity).

Can also reduce Cu(2+) to Cu(1+) (PubMed:16609065).

Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (PubMed:17482547).

Associated with obesity and insulin-resistance (By similarity).

Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107).

Inhibits anchorage-independent cell proliferation (By similarity).

{ECO:0000250|UniProtKB:Q687X5, ECO:0000269|PubMed:16609065, ECO:0000269|PubMed:17482547, ECO:0000269|PubMed:19660107}.