Mouse Stimulated by retinoic acid gene 8 protein homolog,STRA8 ELI
3,140.00 ₪
Meiosis-inducer required for the transition into meiosis for both female and male germ cells (PubMed:16461896, PubMed:17115059, PubMed:18799751, PubMed:18799790, PubMed:19805549, PubMed:32054698, PubMed:32032549).
In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase (PubMed:16461896, PubMed:17115059, PubMed:18799751, PubMed:18799790, PubMed:32054698).
During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation (PubMed:25902548).
In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis (PubMed:19805549, PubMed:32032549).
{ECO:0000269|PubMed:16461896, ECO:0000269|PubMed:17115059, ECO:0000269|PubMed:18799751, ECO:0000269|PubMed:18799790, ECO:0000269|PubMed:19805549, ECO:0000269|PubMed:25902548, ECO:0000269|PubMed:32032549, ECO:0000269|PubMed:32054698}.
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