Mouse Suppressors of Cytokine Signaling 1, SOCS-1 ELI

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.

SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway (PubMed:15522878). Through binding to JAKs and IFNGR1, inhibits their kinase activity (PubMed:9202125). In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF) (PubMed:9202125). Regulates interferon-gamma (IFNG) mediated sensory neuron survival.

Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Seems to recognize JAK2 (By similarity). SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity).