Mouse Toll-like receptor 7,TLR7 ELI

Endosomal receptor that plays a key role in innate and adaptive immunity.

Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:21402738).

Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction.

In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:14976261) (By similarity).

{ECO:0000250|UniProtKB:Q9NYK1, ECO:0000269|PubMed:14976261, ECO:0000269|PubMed:21402738}.