Mouse Transcription Factor SOX 18,SOX18 ELI
3,140.00 ₪
Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis (PubMed:7651823, PubMed:10742113, PubMed:12748961, PubMed:18931657, PubMed:19429912, PubMed:26939885).
Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers (PubMed:18931657, PubMed:26939885).
Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells (PubMed:18931657).
Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17 (PubMed:16895970).
Interaction with MEF2C enhances transcriptional activation (PubMed:11554755).
Besides, required for normal hair development (PubMed:11094083, PubMed:12748961).
{ECO:0000269|PubMed:10742113, ECO:0000269|PubMed:11094083, ECO:0000269|PubMed:11554755, ECO:0000269|PubMed:12748961, ECO:0000269|PubMed:16895970, ECO:0000269|PubMed:18931657, ECO:0000269|PubMed:19429912, ECO:0000269|PubMed:26939885, ECO:0000269|PubMed:7651823}.
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