Mouse Transcription Factor SOX 2,SOX2 ELI
3,140.00 ₪
Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739).
Binds to the proximal enhancer region of NANOG (PubMed:15863505).
Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity).
Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669).
Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
May function as a switch in neuronal development (By similarity).
{ECO:0000250|UniProtKB:P48430, ECO:0000250|UniProtKB:P48431, ECO:0000269|PubMed:15863505, ECO:0000269|PubMed:17097055, ECO:0000269|PubMed:19740739, ECO:0000269|PubMed:22198669}.
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