Mouse Transcription Factor Sp1, SP1 ELI

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli.

Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses.

Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation).

Binds also the PDGFR-alpha G-box promoter.

May have a role in modulating the cellular response to DNA damage.

Implicated in chromatin remodeling.

Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity).

Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed: 24030830).

Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (PubMed: 27918959).