Mouse tRNA pseudouridine synthase Pus10,PUS10 ELI

Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm.

In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs.

tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs.

In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity.

Binds pri-miRNAs.

Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage.

Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.

{ECO:0000250|UniProtKB:Q3MIT2}.