Mouse Tsukushin, TSKU ELI

Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways (PubMed: 21856951, PubMed: 22995554, PubMed: 25159578, PubMed: 31391339).

Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye (PubMed: 21856951).

Plays a role in regulating the hair cycle by controlling TGFB1 signaling (PubMed: 22995554).

Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth (PubMed: 21055390, PubMed: 23206892).

Essential for terminal differentiation of hippocampal neural stem cells (PubMed: 31983064).

Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size (PubMed: 30271858).

Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells (PubMed: 32127020).

Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence (PubMed: 25159578).

Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver (PubMed: 31391339).

In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure (PubMed: 31535079).

In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis (PubMed: 31767170).