Mouse Tubulin Beta-3 Chain, TUBB3 ELI

Tubulin is the major constituent of microtubules.

It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

TUBB3 plays a critical role in proper axon guidance and mantainance.

Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed: 28483977).

Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity).