Mouse Tumor Necrosis Factor Receptor Superfamily Member 10B, TNFRSF10B ELI

Receptor for the cytotoxic ligand TNFSF10/TRAIL.

The adapter molecule FADD recruits caspase-8 to the activated receptor.

The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Promotes the activation of NF-kappa-B.

Essential for ER stress-induced apoptosis.