Mouse Tyrosine-protein phosphatase non-receptor type 11,PTPN11 ELI

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:14967142).

Positively regulates MAPK signal transduction pathway (By similarity).

Dephosphorylates GAB1, ARHGAP35 and EGFR (By similarity).

Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (By similarity).

Dephosphorylates CDC73 (By similarity).

Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (PubMed:29644115).

{ECO:0000250|UniProtKB:Q06124, ECO:0000269|PubMed:14967142, ECO:0000269|PubMed:29644115}.