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Mouse Tyrosine-protein Phosphatase Non-receptor Type 4, PTPN4 ELI

Price

‏3,140.00 ‏₪

Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed: 17953619, PubMed: 25825441).

Regulates neuronal cell homeostasis by protecting neurons against apoptosis (By similarity).

Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed: 25825441).

Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (PubMed: 18614237).

May act at junctions between the membrane and the cytoskeleton.

Package Size

Quantity

Storage and Stability

2-8ºC

Sensitivity

1.27ng/L

Detection range

2-600ng/L

Shipping Conditions

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