Mouse Zinc finger E-box-binding homeobox 1 ,ZEB1 ELI

Acts as a transcriptional repressor.

Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes.

Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1.

Represses BCL6 transcription in the presence of the corepressor CTBP1 (By similarity).

Positively regulates neuronal differentiation.

Represses RCOR1 transcription activation during neurogenesis.

Represses transcription by binding to the E box (5'-CANNTG-3').

Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

{ECO:0000250, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20346398}.