Mouse Zinc Finger Homeobox Protein 3,ZFHX3 ELI

Transcriptional regulator which can act as an activator or a repressor.

Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence.

In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (By similarity).

Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (PubMed:26232227).

Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression.

Down-regulates the MUC5AC promoter in gastric cancer.

In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (By similarity).

{ECO:0000250|UniProtKB:Q15911, ECO:0000269|PubMed:26232227}.