Porcine Beclin 1,BECN1 ELI

Plays a central role in autophagy.

Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis.

Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2.

Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms.

Involved in endocytosis.

May play a role in antiviral host defense (By similarity).

{ECO:0000250|UniProtKB:O88597, ECO:0000250|UniProtKB:Q14457, ECO:0000250|UniProtKB:Q91XJ1}.; Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.

{ECO:0000250|UniProtKB:O88597, ECO:0000250|UniProtKB:Q14457}.