Porcine Insulin-like Growth Factors Binding Protein 3, IGFBP3 ELI

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.

They alter the interaction of IGFs with their cell surface receptors.

Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.