Porcine Integrin beta-2,ITGB2 ELI

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4.

Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL.

Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen.

Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain.

Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain.

Integrin ITGAM/ITGB2 is also a receptor for factor X.

Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1.

Contributes to natural killer cell cytotoxicity.

Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils.

Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.

Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.

{ECO:0000250|UniProtKB:P05107}.