Porcine Peroxisome Proliferation Activated Receptor Gamma, PPARG ELI

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids.

Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase.

It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.

Key regulator of adipocyte differentiation and glucose homeostasis.

ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer.

Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.

Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.