Porcine Prostaglandin reductase 1,PTGR1 ELI

NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:8576264, PubMed:9461497, PubMed:10837478, PubMed:11688989).

Preferentially uses NADPH over NADH as cofactor (PubMed:9461497).

Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:9461497, PubMed:11688989).

Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (PubMed:8576264, PubMed:8394361).

Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4 and may promote neutrophil recruitment at the inflammatory site (PubMed:10837478, PubMed:11688989).

Plays a role in metabolic detoxification of alkenals and ketones.

Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (By similarity).

May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity).

{ECO:0000250|UniProtKB:P97584, ECO:0000250|UniProtKB:Q14914, ECO:0000269|PubMed:10837478, ECO:0000269|PubMed:11688989, ECO:0000269|PubMed:8394361, ECO:0000269|PubMed:8576264, ECO:0000269|PubMed:9461497}.