Porcine Scavenger Receptor Cysteine-rich Type 1 Protein M130, CD163 ELI

Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage.

May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme.

Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner.

Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity).

May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV).

In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.

After shedding, the soluble form (sCD163) may play an anti-inflammatory role.