Rabbit Ryanodine receptor 2,RyR2 ELI

Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction.

Aberrant channel activation can lead to cardiac arrhythmia.

In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C.

Required for cellular calcium ion homeostasis.

Required for embryonic heart development (By similarity).

The calcium channel activity is modulated by formation of heterotetramers with RYR3.

{ECO:0000250|UniProtKB:Q92736, ECO:0000269|PubMed:12213830}.