Rat 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial,CYP24A1 ELI
3,140.00 ₪
A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis.
Via C24-oxidation pathway, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:2026586, PubMed:16617161, PubMed:10231362).
With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid (PubMed:10231362, PubMed:16617161).
Hydroxylates at C-24 or C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol (PubMed:25727742).
Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:2026586).
{ECO:0000269|PubMed:10231362, ECO:0000269|PubMed:16617161, ECO:0000269|PubMed:2026586, ECO:0000269|PubMed:25727742}.
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