Rat 5-Hydroxytryptamine Receptor 1B,HTR1B ELI

G-protein coupled receptor for 5-hydroxytryptamine (serotonin).

Also functions as a receptor for various alkaloids and psychoactive substances.

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.

Signaling inhibits adenylate cyclase activity.

Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.

Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior.

Besides, plays a role in vasoconstriction of cerebral arteries.

{ECO:0000269|PubMed:1836757, ECO:0000269|Ref.1}.