Rat 5-Hydroxytryptamine Receptor 2A, HTR2A ELI

G-protein coupled receptor for 5-hydroxytryptamine (serotonin).

Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD).

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.

Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.

Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores.

Affects neural activity, perception, cognition and mood.

Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances.

Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.