Rat adenosine deaminase,ADA ELI

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.

Plays an important role in purine metabolism and in adenosine homeostasis.

Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events.

Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.

Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion.

Enhances CD4+ T-cell differentiation and proliferation.

Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change.

Stimulates plasminogen activation.

Plays a role in male fertility.

Plays a protective role in early postimplantation embryonic development.

{ECO:0000250|UniProtKB:P00813, ECO:0000250|UniProtKB:P03958, ECO:0000250|UniProtKB:P56658}.