Rat Arginase-2, ARG2 ELI

May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis.

Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid Synthase (NOS).

Arginine metabolism is a critical regulator of innate and adaptive immune responses.

Seems to be involved in negative regulation of the survival capacity of activated T cells.

May suppress inflammation-related signaling in asthmatic airway epithelium.

May play a role in promoting prenatal immune suppression.

Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction.

Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling.

Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity.