Rat Atrial Natriuretic Peptide-converting Enzyme, CORIN ELI

Serine-type endopeptidase involved in atrial natriuretic Peptide (NPPA) processing (PubMed: 17660514).

Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation (By similarity).

Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (By similarity).

Also acts as a regulator of sodium reabsorption in kidney (PubMed: 20613715).

May also process pro-NPPB the B-type natriuretic Peptide (By similarity).