Rat Beta-glucuronidase, BETA GD ELI

Beta-glucuronidases are members of the glycosidase family of enzymes that catalyze breakdown of complex carbohydrates.

Human β-glucuronidase is a type of glucuronidase (a member of glycosidase Family 2) that catalyzes hydrolysis of β-D-glucuronic acid residues from the non-reducing end of mucopolysaccharides (also referred to as glycosaminoglycans) such as heparan sulfate.

Human β-glucuronidase is located in the lysosome.

In the gut, brush border β-glucuronidase converts conjugated bilirubin to the unconjugated form for reabsorption.

Beta-glucuronidase is also present in breast milk, which contributes to neonatal jaundice.

The protein is encoded by the GUSB gene in humans and by the uidA gene in bacteria.