Rat Beta-Site APP Cleaving Enzyme 1,BACE1 ELI

Responsible for the proteolytic processing of the amyloid precursor protein (APP).

Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity).

Cleaves CHL1 (By similarity).

{ECO:0000250|UniProtKB:P56817, ECO:0000250|UniProtKB:P56818}.