Rat beta-site APP-cleaving enzyme 2;Beta-secretase 2,BACE2 ELI

Responsible for the proteolytic processing of the amyloid precursor protein (APP).

Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

It has also been shown that it can cleave APP between residues 671 and 672 (By similarity).

Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (By similarity).

{ECO:0000250|UniProtKB:Q9Y5Z0}.