Rat Bridging Integrator 1,BIN1 ELI

Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling.

Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling.

Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (By similarity).

Is a negative regulator of endocytosis (PubMed:9736607, PubMed:27760323).

Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (By similarity).

In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (PubMed:27760323).

May be involved in the regulation of MYC activity and the control cell proliferation (By similarity).

{ECO:0000250|UniProtKB:O00499, ECO:0000250|UniProtKB:O08539, ECO:0000269|PubMed:27760323, ECO:0000269|PubMed:9736607}.