Rat Calcium;Calmodulin-Dependent Protein Kinase 2 Alpha,CAMK2A ELI
3,140.00 ₪
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation.
Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654).
Regulates dendritic spine development.
Also regulates the migration of developing neurons.
Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity).
Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity).
{ECO:0000250|UniProtKB:P11798, ECO:0000250|UniProtKB:Q9UQM7, ECO:0000269|PubMed:15312654}.
Quantity