Rat Calcium/Calmodulin-dependent Protein Kinase-2, CAMK 2 ELI

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes.

Phosphorylates CAMK1 and CAMK4.

Phosphorylates CAMK1D (By similarity).

Seems to be involved in hippocampal activation of CREB1 (By similarity).

Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1.

This phosphorylation is stimulated in response to Ca(2+) signals.

May play a role in neurite growth.

Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching.