Rat cluster of differentiation 14,CD14 ELI

Coreceptor for bacterial lipopolysaccharide.

In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS).

Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway.

Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).

{ECO:0000250|UniProtKB:P08571, ECO:0000250|UniProtKB:P10810}.