Rat CREB Binding Protein,CREBBP ELI

Acetylates histones, giving a specific tag for transcriptional activation (By similarity).

Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (By similarity).

Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes.

Acts as a coactivator of ALX1.

Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (By similarity).

Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (By similarity).

Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (By similarity).

Acetylates DDX21, thereby inhibiting DDX21 helicase activity (By similarity).

Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (By similarity).

Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (By similarity).

{ECO:0000250|UniProtKB:P45481, ECO:0000250|UniProtKB:Q92793}.