Rat Cysteine and Glycine-rich Protein 3, CSRP3 ELI

Positive regulator of myogenesis.

Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6.

Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (PubMed: 7954791, PubMed: 9234731).

Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes.

Could play a role in mechanical stretch sensing.

May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures.

It is essential for calcineurin anchorage to the Z line.

Required for stress-induced calcineurin-NFAT activation.

The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly.

Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism.

Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association.

In vitro can inhibit PKC/PRKCA activity.

Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity).