Rat Dimethylaniline Monooxygenase [N-oxide-forming] 3, FMO3 ELI

Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds.

Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite.

TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.

By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.