Rat Disrupted in schizophrenia 1 protein,DISC1 ELI

Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:17035248).

Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus.

Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance.

Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation.

Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A.

Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development.

Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity).

Plays a role, together with PCNT, in the microtubule network formation (By similarity).

{ECO:0000250|UniProtKB:Q811T9, ECO:0000250|UniProtKB:Q9NRI5, ECO:0000269|PubMed:17035248}.