Rat Epoxidehydrolase 1, EPHX1 ELI

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.

May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids.

Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity).