Rat Formin-binding protein 1,FNBP1 ELI
3,140.00 ₪
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis.
Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules.
Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex.
Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles.
May be required for the lysosomal retention of FASLG/FASL (By similarity).
May act as a link between RND2 signaling and regulation of the actin cytoskeleton.
Isoform 1 and isoform 2 promote RND2-induced neurite branching in neuronal cells.
{ECO:0000250, ECO:0000269|PubMed:12244061, ECO:0000269|PubMed:14732713}.
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